朱亚辉:国家级青年人才

编辑:刘念 发布时间:吃阴吃到流水的视频3-11-17 17:41

 

职位:弘深青年学者、教授、博士研究生导师

Email: zhuyahui@whu.edu.cn

 

学习经历:

2012/09-2017/06 武汉大学生命科学学院 博士

2006/09-2010/06 重庆工商大学         学士

工作经历:

吃阴吃到流水的视频1/04-至今,吃阴吃到流水的视频,教授

2018/03-吃阴吃到流水的视频1/03,武汉大学生命科学学院,助理研究员

2017/08-吃阴吃到流水的视频1/03,武汉大学生命科学学院,博士后

2011/05-2012/09,陆军军医大学基础部,科研助理

研究方向

本实验室主要从事肿瘤代谢、肿瘤免疫和靶向治疗的前沿基础研究:

1. 代谢重编程与肿瘤发生;

2. 代谢与肿瘤免疫逃逸;

3. 肿瘤靶向治疗和免疫治疗。

代表性论文(#第一作者,*通讯作者)

1. Zhu Y#, Gu L#, Lin X, Liu C, Lu B, Cui K, Zhou F, Zhao Q, Prochownik EV, Fan C, Li Y*. Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis. Molecular Cell. 吃阴吃到流水的视频0;77(1):138-149.

2. Zhu Y#, Gu L#, Lin X, Lu B, Liu C, Zhou X, Karin M, Prochownik EV, Li Y*. P53 Deficiency Increases Cholesterol Esterification to Exacerbate Hepatocarcinogenesis. The Journal of Clinical Investigation. Revised.

3. Zhu Y*, Gu L, Lin X, Lu B, Cheng L, Zhou X, Lei C, Zhou F, Zhao Q, Prochownik EV, Li Y*. USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1. Cell Reports. Revised.

4. Zhu Y, Gu L, Lin X, Cui K, Liu C, Lu B, Zhou F, Zhao Q, Shen H, Li Y*. LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of β-catenin. Cell Death & Differentiation. 吃阴吃到流水的视频0;27(4):1316-1327.

5. Zhu Y#, Gu L#, Li Y, Lin X, Shen H, Chen L, Zhong B, Li Y*. miR-148a inhibits colitis and colitis-associated tumorigenesis in mice. Cell Death & Differentiation. 2017;24(12):2199-2209.

6. Zhu Y*, Gu L, Lin X, Zhang J, Tang Y, Lu B, Liu C, Lin X, Zhou X, Prochownik EV, Li Y*. Ceramide-mediated gut dysbiosis Enhances Cholesterol Esterification and Promotes Colorectal Tumorigenesis in mice. (in submission).

7. Gu L#, Zhu Y#, Lin X, Lu B, Zhou X, Zhou F, Zhao Q, Prochownik EV, Li Y*. The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis. Hepatology. 吃阴吃到流水的视频1;73(1):160-174.

8. Gu L#, Zhu Y#, Lin X, Li Y, Cui K, Prochownik EV, Li Y*. Amplification of Glyceronephosphate O-Acyltransferase and Recruitment of USP30 Stabilize DRP1 to Promote Hepatocarcinogenesis. Cancer Research. 2018;78(20):5808-5819.

9. Chen L*, Zhu Y*, Han H, Shen H, Zhang Q, Li Y*. MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice. Cell Death & Disease. 2017;8(7):309. e2916.

10. Gu L*, Zhu Y, Lin X, Tan X, Lu B, Li Y*. Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis. Oncogene. 吃阴吃到流水的视频0;39(11):2437-2449.

11. Han H, Sun D, Li W, Shen H, Zhu Y, Li C, Chen Y, Lu L, Li W, Zhang J, Tian Y, Li Y*. A c-Myc-MicroRNA functional feedback loop affects hepatocarcinogenesis. Hepatology. 2013;57(6): 2378-2389.

12. Han H, Li W, Shen H, Zhang J, Zhu Y, Li Y*. microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect. Journal of Molecular Cell Biology. 2016;8(5):400-410.

13. Li Y*, Zhu Y, Prochownik EV. MicroRNA-based screens for synthetic lethal interactions with c-Myc. RNA & Disease 2016;3(3):e1330.

主持课题项

1. 国家自然科学基金青年基金:肠道微生物厚壁菌促进结直肠细胞癌变的分子机制研究(81802782),主持

2. 中国博士后科学基金特别资助:PGAM5去磷酸化ME1促进脂代谢和肠癌生长的分子机理研究(2019T120682),主持

3. 中国博士后基金面上资助:miR-148a缺失改变肠道菌群平衡而促进肠癌发生的机制,(2018M632915),主持